Activity of phosphatase-sensitive 5-aminolevulinic acid prodrugs in cancer cell lines
نویسندگان
چکیده
منابع مشابه
[Apoptosis-inducing effect of 5-aminolevulinic acid-mediated photodynamic therapy (5-ALA-PDT) on cervical cancer cell lines].
BACKGROUND & OBJECTIVE 5-Aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is a new ablation treatment for tumors, while its function mechanism in cervical cancer is unclear. This study was to investigate the effects of ALA-PDT on cervical cancer cell lines. METHODS The effects of ALA-PDT on proliferation of 8 human cervical cancer cell lines were examined by MTT assay to find out t...
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BACKGROUND 5-Aminolevulinic acid (ALA) and its derivatives have been widely used in photodynamic therapy. The main drawback associated with ALA-based photodynamic therapy (ALA-PDT) and ALA fluorescence diagnosis results from the hydrophilic nature of ALA and lack of selectivity for tumor versus nontumor cells. The application of certain triggers, such as pH, into conventional sensitizers for co...
متن کامل5-aminolevulinic acid-based photodynamic therapy in leukemia cell HL60.
A study to explore the optimal experimental parameters and the photosensitization of 5-aminolevulinic acid (ALA)-based photodynamic therapy (PDT) in promyelocytic leukemia cell HL60 has been conducted, in which HL60 cells and their control groups, peripheral blood mononuclear cell (PBMC), first are incubated with different concentrations of ALA in dark for different periods of time and then fol...
متن کاملCytotoxic Activity of Juniperus excelsa M. Bieb. Leaves Essential Oil in Breast Cancer Cell Lines
Background and objectives: Juniperus excelsa is a flowering plant that has been applied as traditional medicine for treatment of various disorders such as dysmenorrhea, bronchitis and colds, jaundice and tuberculosis. The aims of the present study were analyzing J. excelsa essential oil and investigation of its cytotoxic activity on three breast cancer cell li...
متن کاملIn vitro antitumor activity of patulin on cervical and colorectal cancer cell lines
Background and Purpose: Patulin is a mycotoxin produced by some molds,especially Aspergillus and Penicilium, and is responsible for mycotoxicosis in animals and humans.There is still not very detailed data about the anti-cancer potency of patulin, but some reports demonstrated that it induces cellular apoptosis and toxicity. Materials and Methods: To determine the efficacy of patulin as a ther...
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ژورنال
عنوان ژورنال: Journal of Photochemistry and Photobiology B: Biology
سال: 2017
ISSN: 1011-1344
DOI: 10.1016/j.jphotobiol.2017.04.029